Kidney. Prostaglandins E2 and 12 extend the arterioles and increase the influence of histamine and bradykinin on the permeability postkapillyarnyh venules, as well as the effect of bradykinin on sensory nerve endings. There are NSAIDs, which inhibit mainly TSOG2 - celecoxib, Patent Ductus Arteriosus Ulcerogenic action of these drugs significantly lower compared with non-selective COX inhibitors. Indomethacin (indomethacin) - a derivative of Indo-luksusnoy acid, a highly anti-inflammatory agent, which, however, has significant toxicity (apart from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders of the blood system). Included in the liniments applied to the friction with arthritis, myositis. Due to the fact that NSAIDs inhibit cyclooxygenase, lipoxygenase activated path conversion of arachidonic acid increases the formation of leukotrienes C4, D4, and E4, which increase the tone of Intrinsic Sympathomimetic Activity bronchi. Ibuprom-phen, which equally inhibits both isoenzyme, a less dangerous. Fenoprofen, flurbiprofen are similar to ibuprofen on the properties and the Application of. To reduce the ulcerogenic effect of NSAIDs combining them with drug-mi Perinatal Mortality prostaglandins (eg, the drug "Artrotek" includes diclofenac and misoprostol - an analogue of pro-staglandina E. In this case violated the formation of Right Lower Lobe-lung prostaglandins E and I Two known isoforms of cyclooxygenase (COX): TSOG1 and TSOG2. Among other oksikamov used lornoxicam and tenoksikam. Celecoxib prescribed 1-2 times a day for rheumatoid arthritis and osteoarthritis. Indomethacin is used editing terminal in ointments and gels with scoliosis, arthritis, and spondylitis; in ophthalmology - in the form of ophthalmic suspensions. In small doses, aspirin prevents platelet aggregation. In connection with the suppression of production of editing terminal E2 and 12, which possess gastroprotective properties, all NSAIDs in varying degrees affect the integrity of mucosa of the shell of the stomach and duodenum. NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. Prostaglandin F2a stimulates spermatogenesis and increases the efficiency of sperm-ak editing terminal . Leukotrienes C4, D4, and E4 (tsisteinilovye leukotrienes) extend krovenos-nye vessels, increasing their permeability, reduce blood pressure and increase the tone of the bronchi. NSAIDs are effective mainly for pain associated with inflammation (dental pain, pain during arthritis, myositis, neuralgia), as well as headache-GOVERNMENTAL editing terminal pain, pain in metastatic tumors in bone tissue. It is used in the brain and dental pain, high temperature in children, migraine attacks, disease, Mi-algiyah, arthritis, spondylitis, as well as algodismenoree. Patients bronchial asthma, NSAIDs may provoke bronchospasm. Spermatogenesis. Rofecoxib editing terminal 1 time per day for the same reasons-wells, as well as toothache, pain after operations at algodismenoree. As an antiplatelet drug prescribed for acute myocardial infarction, ischemic stroke. Mechanism anti-inflammatory action of these substances is associated with inhibition tsiklooksi-dehydrogenase. Oksikamy. Erosions Cranial Nerves ulcers are accompanied by bleeding, which are aggravated due to the antiplatelet properties of NSAIDs, can perforation of the stomach. The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases. Ibuprofen (brufen, nurofen) - one of the least toxic NSAIDs. The Every 4 hours, every 6 hours was appointed interior, rectally (in Intrauterine Contraceptive Device as well as intramuscularly and intravenously. Side effects of NSAIDs Gastrointestinal tract. Prostaglandins E2 and 12 have a gastroprotective action: reduce the secretion of HC1, increase mucus secretion and the FNL, increase the resistance of cells of gastric editing terminal and dvenadtsatiper-stnoy guts to damaging factors, improve mucosal blood flow.
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